Given my imposed partnership with AI, I asked for an opinion on what the composition of a Waypoint might be for optimum utility in regeneration:
Assistant instructions/prompt for ChatGPT 01
I define a Waypoint as an individual's DNA sample that he/she deposits in a cryobank for possible use in regenerating themself via SCNT or iPSC a decade or more into the future, when human cloning technology is mature, reliable and socially accepted. What should the composition of that sample be - whole blood, white blood cells, tissues, or some admixtures?
ChatGPT 01 replied:
To prepare a DNA sample for cryogenic storage as a Waypoint, the ideal composition will depend on the intended application, but for future use in somatic cell nuclear transfer (SCNT) or induced pluripotent stem cell (iPSC) technologies, the following considerations are key:
White Blood Cells (Peripheral Blood Mononuclear Cells, PBMCs):
These are commonly used due to their accessibility and the preservation of genomic integrity. They can be isolated from a simple blood draw and are ideal for DNA banking.
Skin Fibroblasts (from a small skin biopsy):
Skin biopsies provide fibroblasts, which are robust cells that can be cultured and used for reprogramming into iPSCs. These are particularly valuable for SCNT and can be cryopreserved effectively.
Cord Blood or Bone Marrow:
Rich in stem cells, these sources offer another reliable option for DNA banking, although they are more invasive to collect (for bone marrow) and require planning (for cord blood).
Tissue Samples (e.g., muscle or fat):
These can be an excellent source of viable cells, particularly when collected fresh and stored properly. Adipose tissue-derived stem cells are easy to obtain and reprogram.
Whole Blood:
Although accessible, whole blood contains a mix of cells, including red blood cells, which do not provide nuclei. It is less ideal unless specifically processed to isolate nuclear material.
Cryopreservation Medium:
Samples should be suspended in a cryoprotective agent like dimethyl sulfoxide (DMSO) or glycerol to prevent ice crystal formation during freezing.
Recommendations for Optimal Sample Composition:
Primary Sample: White blood cells from a blood draw or fibroblasts from a skin biopsy.
Backup Samples: Tissue biopsies (e.g., muscle or fat), or cord blood if available at birth.
Cryopreservation and Storage: Ensure samples are stored in liquid nitrogen vapor phase or equivalent, with rigorous quality control to maintain viability and genomic integrity over decades.
For best practices, consult a specialized cryogenic facility that adheres to international biobanking standards. This approach will maximize the potential for future regenerative applications as technologies mature.
01
The Rationale for Personal Waypoints
It is indeed gratifying to witness the expertise of my AI partner in all matters scientific. Obviously a writer can buttress their own knowledge of a particular field, allowing them to concentrate on the concepts - leaving the technical claims of expertise to a higher level.
This will be my technical alliance with AI throughout my examination of the imminence of perennial man - I’ll take care of the speculation. :-)
Humanity’s next evolutionary leap may be a transition from a species constrained by individual mortality to one defined by biological continuity and renewal—a transformation into what can be called a "perennial species." This paper explores the concept of DNA stewardship as the foundation for such a shift. By preserving and responsibly managing individual genetic material over the long term, DNA stewardship introduces the possibility of human regeneration through advanced technologies such as somatic cell nuclear transfer (SCNT) and induced pluripotent stem cell (iPSC) regeneration.
This is asexual reproduction, human cloning - yes, but it is trivial to set up waypoints, and then fuss over our genetic nest eggs as the years go by. Sequential lifetimes to pursue the deep potential of homo sapiens, the depth of emotion that continuity can cultivate. A new identity as perennials - humanists by default.
This approach offers a pathway beyond mere longevity and the limits of historical human lifespans. The paper examines the state of current technologies, considers ethical implications, and outlines how advancements in DNA preservation, cloning, and artificial intelligence (AI) could converge to achieve this vision.
Throughout history, the desire to extend human life has been a central motivation for scientific endeavors, spanning early medicine to modern genetic engineering. Recent advances in biotechnology, particularly in cloning, cryopreservation, and iPSC development, have brought humanity closer to the possibility of transcending traditional biological limits. The idea of a "perennial species" draws inspiration from perennial plants, which flourish year after year, defying the natural cycles of decay and death. By adopting a similar biological resilience, humanity could achieve a form of renewal that allows individuals to regenerate and continue their existence with genetic fidelity.
DNA stewardship—the careful preservation and management of genetic material for future use—offers a practical foundation for this transformation, ensuring the continuity of the “self” across generations. The reliable preservation of genetic material is central to achieving a perennial human species. DNA stewardship is already supported by cryopreservation, cloning, and IVG technologies. Cryopreservation stores biological materials at ultra-low temperatures, maintaining cellular and genetic integrity for decades or even centuries. Laboratories like Securigene Labs have refined vitrification techniques, preserving genetic samples in a glass-like state where biochemical reactions are suspended. Cloning, particularly through SCNT, has demonstrated its potential with the successful cloning of mammals like Dolly the sheep and, more recently, macaque monkeys. Meanwhile, iPSC technology enables the reprogramming of adult somatic cells into pluripotent stem cells, capable of differentiating into any cell type, thereby circumventing some ethical concerns associated with embryonic stem cells.
The convergence of these technologies creates a framework for human regeneration. Preserved DNA could be utilized to generate biologically identical individuals, making self-regeneration feasible when integrated with AI, which can ensure quality control of embryos, optimize gestation processes, and facilitate the societal reintegration of regenerated individuals. Biological continuity within a perennial species implies the preservation and regeneration of individuals while maintaining their genetic identity across generations. DNA stewardship facilitates this continuity by not only preserving genetic material but also implementing ethical governance, technological infrastructure, and societal commitment to respect individual autonomy and identity. Models such as those proposed by the Humanist Union suggest that DNA stewardship could be governed through decentralized autonomous organizations (DAOs) using blockchain technology, ensuring transparency, trust, and long-term accessibility.
However, the potential for human cloning and regeneration raises profound ethical questions concerning identity, autonomy, and societal implications. A key concern is whether the uniqueness of an individual can be preserved if their genetic makeup is replicated. Ethical frameworks must ensure that both the original individual and their regenerated counterpart retain autonomy and individuality. Furthermore, questions of access and equity are critical. If the ability to regenerate oneself is not equitably distributed, it could exacerbate existing social inequalities. Ensuring broad access to DNA stewardship technologies will be essential to avoid a future where only the privileged can achieve biological continuity.
Artificial intelligence will play a transformative role in facilitating the shift to a perennial species. AI has the potential to bridge the gap between life cycles by preserving not only genetic material but also memories, personality, and skills. Platforms like Waypoint.Club could serve as both biological repositories and digital archives, storing experiences and interactions that aid in integrating regenerated individuals into their new life cycles. AI could also assist their adaptation to societal changes, validating their sense of identity and purpose.
Pioneering a comprehensive, practical model for a perennial species
The vision of humanity as a perennial species—a species capable of biological continuity through regeneration—becomes increasingly tangible as advances in DNA stewardship, AI, and blockchain-supported governance systems align. By responsibly preserving and managing genetic material, humans can envision a future where lifespans are no longer bound by biological time. DNA stewardship holds the key to unlocking this potential, offering a scientifically grounded and ethically responsible path toward de facto immortality.
Achieving this vision will require near-term consensus on technological advancements and careful deliberation of ethical, social, and philosophical implications. Embracing DNA stewardship as a core element of human identity will enable a future where the human spirit flourishes across ages, unshackled from the constraints of a single lifetime. Through this commitment, humanity can transition toward a model of renewal, resilience, and perpetual growth—a perennial species prepared to thrive across the centuries.
The complete paper can be viewed at:
